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Panama and Colombia: Exploring the Caribbean Coast

Discover an astonishing trove of natural and cultural treasures as you navigate the Caribbean coast of Panama and Colombia aboard the National Geographic Quest. Hike into dense rainforests that harbor extraordinary biodiversity, glide through little-explored inlets by Zodiac and kayak, and meet the indigenous inhabitants of a secluded Panamanian archipelago where age-old traditions remain part of everyday life. Experience the diverse heritage of stunning cities and remote towns off the beaten path, from the Arab-influenced architecture of Colombia’s Santa Cruz de Lorica to the bustling shores of Santa Cruz del Islote—the most densely populated island in the world.

31 October, 2026 to 07 November, 2026
Category 01 $10,641 AUD pp
#301-306 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, two portholes, full length mirror, and reading lights.
view cabin photo
Category 02 $11,384 AUD pp
#307-315 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, two portholes, full length mirror, and reading lights.
view cabin photo
Category 03 $12,176 AUD pp
#201-206 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, a large view window, full-length mirror, and reading lights.
view cabin photo
Category 04 $14,619 AUD pp
#207-229 — Cabins feature two single beds that can convert to a Queen, a writing desk, closet, two nightstands, full-length mirror, reading lights, sliding glass door, and a small, private balcony.
view cabin photo
Category 05 $16,087 AUD pp
#101-108 — These suites feature two single beds that can convert to a Queen, a convertible sofa bed that can accommodate a third person, large view windows, closet, two nightstands, full-length mirror, reading lights, writing desk, ample storage space, espresso maker and an oversized bathroom. Guests receive complimentary laundry and priority access to one spa appointment per departure.
view cabin photo
07 November, 2026 to 14 November, 2026 (reverse)
Category 01 $7,571 AUD pp
#301-306 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, two portholes, full length mirror, and reading lights.
view cabin photo
Category 02 $8,257 AUD pp
#307-315 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, two portholes, full length mirror, and reading lights.
view cabin photo
Category 03 $9,000 AUD pp
#201-206 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, a large view window, full-length mirror, and reading lights.
view cabin photo
Category 04 $11,171 AUD pp
#207-229 — Cabins feature two single beds that can convert to a Queen, a writing desk, closet, two nightstands, full-length mirror, reading lights, sliding glass door, and a small, private balcony.
view cabin photo
Category 05 $12,514 AUD pp
#101-108 — These suites feature two single beds that can convert to a Queen, a convertible sofa bed that can accommodate a third person, large view windows, closet, two nightstands, full-length mirror, reading lights, writing desk, ample storage space, espresso maker and an oversized bathroom. Guests receive complimentary laundry and priority access to one spa appointment per departure.
view cabin photo
Category 2. From $13,904 AUD pp
12 November, 2027 to 19 November, 2027
Category 01 $9,627 AUD pp
#301-306 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, two portholes, full length mirror, and reading lights.
view cabin photo
Category 02 $10,299 AUD pp
#307-315 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, two portholes, full length mirror, and reading lights.
view cabin photo
Category 03 $11,015 AUD pp
#201-206 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, a large view window, full-length mirror, and reading lights.
view cabin photo
Category 04 $13,224 AUD pp
#207-229 — Cabins feature two single beds that can convert to a Queen, a writing desk, closet, two nightstands, full-length mirror, reading lights, sliding glass door, and a small, private balcony.
view cabin photo
Category 05 $14,552 AUD pp
#101-108 — These suites feature two single beds that can convert to a Queen, a convertible sofa bed that can accommodate a third person, large view windows, closet, two nightstands, full-length mirror, reading lights, writing desk, ample storage space, espresso maker and an oversized bathroom. Guests receive complimentary laundry and priority access to one spa appointment per departure.
view cabin photo
19 November, 2027 to 26 November, 2027 (reverse)
Category 01 $8,664 AUD pp
#301-306 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, two portholes, full length mirror, and reading lights.
view cabin photo
Category 02 $9,269 AUD pp
#307-315 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, two portholes, full length mirror, and reading lights.
view cabin photo
Category 03 $9,913 AUD pp
#201-206 — Cabins feature two single beds that can convert to a Queen, a writing desk, two nightstands, a large view window, full-length mirror, and reading lights.
view cabin photo
Category 04 $11,901 AUD pp
#207-229 — Cabins feature two single beds that can convert to a Queen, a writing desk, closet, two nightstands, full-length mirror, reading lights, sliding glass door, and a small, private balcony.
view cabin photo
Category 05 $13,097 AUD pp
#101-108 — These suites feature two single beds that can convert to a Queen, a convertible sofa bed that can accommodate a third person, large view windows, closet, two nightstands, full-length mirror, reading lights, writing desk, ample storage space, espresso maker and an oversized bathroom. Guests receive complimentary laundry and priority access to one spa appointment per departure.
view cabin photo

Panama and Colombia: Exploring the Caribbean Coast itinerary:

show reverse itinerary
DAY 1: Panama City, Panama

Upon arrival in Panama City, transfer to the port in Fuerte Amador and embark our ship. (D)

DAY 2: Gatún Lake

By special permission, our ship anchors overnight in Gatún Lake, a vast artificial lake that forms a major part of the Panama Canal. In the morning, disembark on Barro Colorado, a hilltop transformed into an island by the damming of the Chagres River to build the Panama Canal. Visit the Smithsonian Tropical Research Institute and learn about initiatives to protect the incredible biodiversity of the surrounding Barro Colorado Nature Monument, one of the most studied areas of tropical forest on the planet and the site of various National Geographic–supported studies. Later, choose to hike into the jungle, navigate the lake by Zodiac, or take a boat ride to the mouth of the Chagres River to explore the Panama Rainforest Discovery Center. Tonight, cruise onward through the complex lock system of the Panama Canal, taking advantage of the nighttime lull in cargo activity. Completed in 1914, the canal is about 50 miles long and sees some 14,000 ships pass through every year. Witness this astonishing feat of engineering under the dramatic golden glow of floodlights. (B,L,D)

DAY 3: Portobelo

This morning, we arrive along Panama’s Caribbean coast and step ashore at the historic town of Portobelo. Named by Cristopher Columbus in 1502, Portobelo, or “beautiful port,” was one of the most important Spanish trading centers in the New World. Explore the town’s 17th- and 18th-century Spanish colonial fortifications, designated a UNESCO World Heritage site. Later, hike into Portobelo’s lush jungles in search of mantled howler monkeys, toucans, and a variety of parrots. In the afternoon, our ship sails further down the Panamanian coast, where we’ll set out with snorkel and fins to explore the vibrant undersea world of the Caribbean. (B,L,D)

DAY 4: Guna Yala

Wake up amid the archipelago of Guna Yala (also known as the San Blas islands), a constellation of 368 tiny, white-sand isles scattered off the northeast coast of Panama. Get to know the indigenous Guna people, one of the first native groups to achieve political autonomy in Latin America. Spend the morning among the thatched huts of an island village, learning about Guna culture and handicrafts. Marvel at the intricate designs of handmade textiles called molas, which harken back to a female tradition of body painting. In the afternoon, explore the vibrant marine world around the islands by snorkel, kayak, and stand- up paddleboard. (B,L,D)

DAY 5: Necoclí, Colombia

Discover the little-explored coastal community of Necoclí and the surrounding region. Our exploration begins with Zodiac excursions into lagoons fringed by mangroves, part of a protected coastal wetlands area. Keep an eye out for wildlife, including a variety of colorful bird species such as great and snowy egrets and Amazon and green kingfishers. After lunch, visit a local cocoa farm, where residents are striving to incorporate the UN’s Sustainable Development Goals into their agricultural community. (B,L,D)

DAY 6: Santa Cruz del Islote / San Bernardo Archipelago / San Antero / Tuchín

Santa Cruz del Islote is one of the most densely populated islands on Earth, where some 600 inhabitants live squeezed together in an area the size of two soccer fields, surrounded by turquoise seas and coral reefs. Stroll the island’s motor-free streets, past brightly painted houses and bustling docks; and experience daily life on this unusual island as you chat with local residents. Later, as we enjoy lunch on-board, we cruise through the San Bernardo archipelago calling at San Antero. Our afternoon excursion takes us to Tuchín, an indigenous village celebrated as the birthplace of the sombrero vueltiao, a type of hat considered a national symbol of Colombia. Observe vueltiao makers at work, and then meet with members of the local Zenú community, known for their ingenious irrigation systems. Return to National Geographic Quest, which will stay at anchor tonight in San Antero. (B,L,D)

DAY 7: Santa Cruz de Lorica / Cispatá Bay

Disembark this morning for our short drive to Santa Cruz de Lorica, a charming riverside town influenced by several waves of immigration from France, Belgium, England, Syria, and Lebanon. Stroll through the central square, overlooked by a stunning Spanish-colonial cathedral and historic buildings in colorful Arabic styles. Return to the ship for lunch and time to relax before embarking on a late afternoon cruise in the rarely explored Cispatá Bay, timed for optimum wildlife spotting as native creatures emerge from their mid-day rest. (B,L,D)

DAY 8: Cartagena

After breakfast on board, disembark in Cartagena and transfer to the airport to connect with your flight home. (B)

Please Note:

Itineraries are subject to change

Panama and Colombia: Exploring the Caribbean Coast reverse itinerary:

show main itinerary
Please Note: *

Itineraries are subject to change

DAY 8: Cartagena *

After breakfast on board, disembark in Cartagena and transfer to the airport to connect with your flight home. (B)

DAY 7: Santa Cruz de Lorica / Cispatá Bay *

Disembark this morning for our short drive to Santa Cruz de Lorica, a charming riverside town influenced by several waves of immigration from France, Belgium, England, Syria, and Lebanon. Stroll through the central square, overlooked by a stunning Spanish-colonial cathedral and historic buildings in colorful Arabic styles. Return to the ship for lunch and time to relax before embarking on a late afternoon cruise in the rarely explored Cispatá Bay, timed for optimum wildlife spotting as native creatures emerge from their mid-day rest. (B,L,D)

DAY 6: Santa Cruz del Islote / San Bernardo Archipelago / San Antero / Tuchín *

Santa Cruz del Islote is one of the most densely populated islands on Earth, where some 600 inhabitants live squeezed together in an area the size of two soccer fields, surrounded by turquoise seas and coral reefs. Stroll the island’s motor-free streets, past brightly painted houses and bustling docks; and experience daily life on this unusual island as you chat with local residents. Later, as we enjoy lunch on-board, we cruise through the San Bernardo archipelago calling at San Antero. Our afternoon excursion takes us to Tuchín, an indigenous village celebrated as the birthplace of the sombrero vueltiao, a type of hat considered a national symbol of Colombia. Observe vueltiao makers at work, and then meet with members of the local Zenú community, known for their ingenious irrigation systems. Return to National Geographic Quest, which will stay at anchor tonight in San Antero. (B,L,D)

DAY 5: Necoclí, Colombia *

Discover the little-explored coastal community of Necoclí and the surrounding region. Our exploration begins with Zodiac excursions into lagoons fringed by mangroves, part of a protected coastal wetlands area. Keep an eye out for wildlife, including a variety of colorful bird species such as great and snowy egrets and Amazon and green kingfishers. After lunch, visit a local cocoa farm, where residents are striving to incorporate the UN’s Sustainable Development Goals into their agricultural community. (B,L,D)

DAY 4: Guna Yala *

Wake up amid the archipelago of Guna Yala (also known as the San Blas islands), a constellation of 368 tiny, white-sand isles scattered off the northeast coast of Panama. Get to know the indigenous Guna people, one of the first native groups to achieve political autonomy in Latin America. Spend the morning among the thatched huts of an island village, learning about Guna culture and handicrafts. Marvel at the intricate designs of handmade textiles called molas, which harken back to a female tradition of body painting. In the afternoon, explore the vibrant marine world around the islands by snorkel, kayak, and stand- up paddleboard. (B,L,D)

DAY 3: Portobelo *

This morning, we arrive along Panama’s Caribbean coast and step ashore at the historic town of Portobelo. Named by Cristopher Columbus in 1502, Portobelo, or “beautiful port,” was one of the most important Spanish trading centers in the New World. Explore the town’s 17th- and 18th-century Spanish colonial fortifications, designated a UNESCO World Heritage site. Later, hike into Portobelo’s lush jungles in search of mantled howler monkeys, toucans, and a variety of parrots. In the afternoon, our ship sails further down the Panamanian coast, where we’ll set out with snorkel and fins to explore the vibrant undersea world of the Caribbean. (B,L,D)

DAY 2: Gatún Lake *

By special permission, our ship anchors overnight in Gatún Lake, a vast artificial lake that forms a major part of the Panama Canal. In the morning, disembark on Barro Colorado, a hilltop transformed into an island by the damming of the Chagres River to build the Panama Canal. Visit the Smithsonian Tropical Research Institute and learn about initiatives to protect the incredible biodiversity of the surrounding Barro Colorado Nature Monument, one of the most studied areas of tropical forest on the planet and the site of various National Geographic–supported studies. Later, choose to hike into the jungle, navigate the lake by Zodiac, or take a boat ride to the mouth of the Chagres River to explore the Panama Rainforest Discovery Center. Tonight, cruise onward through the complex lock system of the Panama Canal, taking advantage of the nighttime lull in cargo activity. Completed in 1914, the canal is about 50 miles long and sees some 14,000 ships pass through every year. Witness this astonishing feat of engineering under the dramatic golden glow of floodlights. (B,L,D)

DAY 1: Panama City, Panama *

Upon arrival in Panama City, transfer to the port in Fuerte Amador and embark our ship. (D)

* = Indicative
Map for Panama and Colombia: Exploring the Caribbean Coast
National Geographic Quest, the ship servicing Panama and Colombia: Exploring the Caribbean Coast

National Geographic Quest

Vessel Type: Expedition Ship

Length: 72 metres

Passenger Capacity: 100 guests (in 50 cabins)

Built: 2017

Built in 2017, National Geographic Quest is a modern expedition vessel purpose-designed for the narrow channels and shallow coves of Pan-American waters. With insights drawn from nearly four decades of exploration in Alaska, Baja California, Costa Rica and beyond, she is perfectly equipped for immersive coastal voyages. Clean-lined and contemporary in design, her expansive glass windows ensure guests are constantly connected to the surrounding landscapes, whether spotting whales in a lagoon or cruising past rainforest-covered shores.

Accommodating 100 guests in 50 comfortable cabins across four decks, Quest features twin Zodiac boarding platforms for swift disembarkation, a shallow draught for close-to-shore navigation, and wide-ranging public areas. Guests can enjoy a relaxed dining experience with sustainable, locally inspired cuisine, unwind on the sundeck, or visit the lounge, gym, or Global Gallery. Open access to the Bridge invites a deeper engagement with navigation and wildlife spotting alongside the Captain and crew. Every detail is crafted to maximise discovery, comfort, and a shared sense of adventure.

Cabin layout for National Geographic Quest
• Transit the Panama Canal over two days to see it by day and in the coolness of night—plus an exclusive stop at the Smithsonian Research Institute on Barro Colorado Island

• Visit the palm-shaded Panamanian archipelago of Guna Yala (formerly San Blas Islands), an autonomous province that is home to the indigenous Guna people, and get immersed in local culture

• Discover the coastal treasures and remote wilderness of Colombia, exploring vibrant villages, pristine beaches, and wildlife-rich jungles

• Explore Colombia’s rainforests, among the most biodiverse on Earth, with almost 1,900 bird species and an astonishing list of approximately 450 mammals